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KMID : 0377619930580090565
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Korean Jungang Medical Journal
1993 Volume.58 No. 9 p.565 ~ p.571
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The Effect of Transdermal 17-β Estradiol Treatment on the Serum Lipid Profiles in Postmenopausal Syndrome Patients
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임용택/Lim, Yong Taik
이진우/김승조/Lee, Jin Woo/Kim, Seung Jo
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Abstract
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We carried out this study to evaluate the effect of the sequential hormonal replacement therapy (HRT) using the Estraderm TTSso patch (CIBA-GEIGY Pharmaceutical Co., U.S.A.) along with m droxyprogesterone acetate 5 mg/day for 12 days on the serum lipid profiles in 34 postmenopausal syndrome patients.
We measured the serum lipid profiles of high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL), LDL/HDL, Cholesterol/HDL, and total cholesterol at the time of pretreatment evaluation and after 3 months´ HRT, respectively.
Pretreatment serum lipid profiles of HDL. LDL, LDL,/HDL, cholesterol/HDL, and total cholesterol levels or ratios were 59.10 ± 11.89 mg/dl, 112.50 - 10.98 mg/dl, 2.09 ± 0.79, 3.10 - 0.35, and 197.50 -16.41 mg/dl, respectively.
Posttreatment serum lipid profiles of HDL, LDL, LDL/HDL, cholesterol/HDL, and total cholesterol levels or ratios were 56.10 ± 9.69 mg/dl, 93.50 ± 17.46 mg/dl, 1.61 ± 0.64, 2.46 ± 0.34, 187.42 ± 26.78 mg/dl, respectively.
Posttreatment serum LDL levels and cholesterol/HDL ratios following HRT showed the statistically significant differences (p= 0.008) in comparison with pretreatment LDL levels and cholesterol/HDL ratios.
Twenty percent (7/34) of Estraderm patch therapy patients complained of minor skin irritation such as skin eruption at the site of Estraderm patch applied.
In conclusions, transdermal 17-β estradiol treatment seemed to bring the favorable effects on the serum lipid profiles in terms of the cardio-protective effect of HRT and was effective to control postmenopausal symptoms and signs in the postmenopausal syndrome patients.
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KEYWORD
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